The extracellular matrix (ECM), one of biology's most overlooked organelles, underlies several key cellular process. Studies of cell biology and signaling have successfully identified many of the signaling pathways nature deploys to coordinate the ECM, and abnormalities in these pathways underlie several diseases. 

Our laboratory aims to better understand the roles of extracellular matrix components, integrins, and their ligands (with particular interest in the secreted protein Mfge8) in regulating nutrient metabolism, tissue remodeling, and smooth muscle function.

 

                                                                                                                                                                     


Affiliated with UCSF's Cardiovascular Research Institute, Department of Medicine, and Lung Biology Center