MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.
Datta R, Gholampour MA, Yang CD, Volk R, Lin S, Podolsky MJ, Arnold T, Rieder F, Zaro BW, Verzi M, Lehner R, Abumrad N, Lizama CO, Atabai K. Cell Rep. 2023 Mar 15;42(3):112249. doi: 10.1016/j.celrep.2023.112249. Online ahead of print. PMID: 36924494
Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover.
Podolsky MJ, Kheyfets B, Beigh AH, Yang CD, Valenzuela CL, Datta R, Wolters PJ, McManus MT, Qi L, Atabai K.
bioRxiv. 2023 Jan 14:2023.01.13.523943. doi: 10.1101/2023.01.13.523943. Preprint. PMID: 36711851
MFGE8 links absorption of dietary fatty acids with catabolism of enterocyte lipid stores through HNF4γ-dependent transcription of CES enzymes.
Ritwik Datta, Mohammad A Gholampour, Christopher D Yang, Regan Volk, Sinan Lin, Michael J Podolsky, Thomas Arnold, Florian Rieder, Balyn W. Zaro, Michael Verzi, Richard Lehner, Nada Abumrad, Carlos O Lizama, Kamran Atabai. bioRxiv. 2022 May 18. https://doi.org/10.1101/2022.05.16.492147
Autoregulation of insulin receptor signaling through MFGE8 and the avb5 integrin
Datta R, Lizama CO, Soltani AK, McKleroy W, Podolsky MJ, Yang CD, Huynh TL, Cautivo KM, Wang B, Koliwad SK, Abumrad NA, Atabai K.
Proc Natl Acad Sci USA. 2021 May 04;118(18):e2102171118. doi:10.1073/pnas.2102171118
CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling
Oguri Y, Shinoda K, Kim H, Alba DL, Bolus WR, Wang Q, Brown Z, Pradhan RN, Tajima K, Yoneshiro T, Ikeda K, Chen Y, Cheang RT, Tsujino K, Kim CR, Greiner VJ, Datta R, Yang CD, Atabai K, McManus MT, Koliwad SK, Spiegelman BM, Kajimura S.
Cell. 2020 Aug 06;S0092-8674(20)30753-4. doi:10.1016/j.cell.2020.06.021
You Say You Want a Resolution (of Fibrosis)
Atabai K, Yang CD, Podolsky MJ.
Am J Respir Cell Mol Biol. 2020 Jul 08;doi:10.1165/rcmb.2020-0182TR
Age-dependent regulation of cell-mediated collagen turnover
Podolsky MJ, Yang CD, Lizama C, Datta R, Huang SK, Nishimura SL, Dallas SL, Wolters P, Le Saux CJ, Atabai K.
JCI Insight. 2020 May 21;5(10):e137519. doi:10.1172/jci.insight.1375192020
Fat fibrosis: friend or foe?
Datta R, Podolsky MJ, Atabai K.
JCI Insight. 2018 Oct 04;3(19):e122289. doi: 10.1172/jci.insight.122289
Autocrine Mfge8 Signaling Prevents Developmental Exhaustion of the Adult Neural Stem Cell Pool
Zhou Y, Bond AM, Shade JE, Zhu Y, Davis CO, Wang X, Su Y, Yoon KJ, Phan AT, Chen WJ, Oh JH, Marsh-Armstrong N, Atabai K, Ming GL, Song H.
Cell Stem Cell. 2018 Sep 06;23(3):444-452.e4. doi: 10.1016/j.stem.2018.08.005
Cell division cycle 7 kinase is a negative regulator of cell-mediated collagen degradation
Podolsky MJ, Gupta D, Ha A, Ta R, Khalifeh-Soltani A, McKleroy W, Datta R, Sheppard D, Atabai K.
Am J Physiol Lung Cell Mol Physiol. 2018 Sep 01;315(3):L360-L370. doi: 10.1152/ajplung.00144.2018
Deletion of MFGE8 Inhibits Neointima Formation upon Arterial Damage
Viola JR, Lemnitzer P, Paulin N, Drechsler M, Naari-Jahantigh M, Maas S, De Jong RJ, Winter J, Schober A, Weber C, Atabai K, Soehnlein O.
Thromb Haemost. 2018 Jun 04;118(7):1340-1342. doi: 10.1055/s-0038-1649522
The Mfge8-α8β1-PTEN pathway regulates airway smooth muscle contraction in allergic inflammation
Khalifeh-Soltani A, Gupta D, Ha A, Podolsky MJ, Datta R, Atabai K.
FASEB J. 2018 May 15:fj201800109R. doi: 10.1096/fj.201800109R
Extracellular matrix in lung development, homeostasis and disease
Zhou Y, Horowitz JC, Naba A, Ambalavanan N, Atabai K, Balestrini J, Bitterman PB, Corley RA, Ding BS, Engler AJ, Hansen KC, Hagood JS, Kheradmand F, Lin QS, Neptune E, Niklason L, Ortiz LA, Parks WC, Tschumperlin DJ, White ES, Chapman HA, Thannickal VJ.
Matrix Biol. 2018 Mar 08;73:77-104. doi: 10.1016/j.matbio.2018.03.005
Inflammatory bone loss associated with MFG-E8 deficiency is rescued by teriparatide
Michalski MN, Seydel AL, Siismets EM, Zweifler LE, Koh AJ, Sinder BP, Aguirre JI, Atabai K, Roca H, McCauley LK.
FASEB J. 2018 Feb 22;32(7):3730-3741. doi: 10.1096/fj.201701238R. Epub 2018 Feb 22
Inhibition of hepatocyte nuclear factor 1b induces hepatic steatosis through DPP4/NOX1-mediated regulation of superoxide
Long Z, Cao M, Su S, Wu G, Meng F, Wu H, Liu J, Yu W, Atabai K, Wang X.
Free Radic Biol Med. 2017 Sep 21;113:71-83. doi: 10.1016/j.freeradbiomed.2017.09.016
Cd36 knockout mice are protected against lithogenic diet-induced gallstones
Xie Y, Cifarelli V, Pietka T, Newberry EP, Kennedy SM, Khalifeh-Soltani A, Clugston R, Atabai K, Abumrad NA, Davidson NO.
J Lipid Res. 2017 Jun 20;58(8):1692-1701. doi: 10.1194/jlr.M077479
Mfge8 regulates enterocyte lipid storage by promoting enterocyte triglyceride hydrolase activity
Khalifeh-Soltani A, Gupta D, Ha A, Iqbal J, Hussain M, Podolsky MJ, Atabai K.
JCI Insight. 2016 Nov 03;1(18):e87418. doi: 10.1172/jci.insight.87418
α8β1 integrin regulates nutrient absorption through an Mfge8-PTEN dependent mechanism
Khalifeh-Soltani A, Ha A, Podolsky MJ, McCarthy DA, McKleroy W, Azary S, Sakuma S, Tharp KM, Wu N, Yokosaki Y, Hart D, Stahl A, Atabai K.
Elife. 2016 Apr 19;5:e13063. doi: 10.7554/eLife.13063
Prevention of gallbladder hypomotility via FATP2 inhibition protects from lithogenic diet-induced cholelithiasis
Tharp KM, Khalifeh-Soltani A, Park HM, Yurek DA, Falcon A, Wong L, Feng R, Atabai K, Stahl A.
Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G855-64. doi: 10.1152/ajpgi.00316.2015
IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction
Bhattacharya M, Sundaram A, Kudo M, Farmer J, Ganesan P, Khalifeh-Soltani A, Arjomandi M, Atabai K, Huang X, Sheppard D.
J Clin Invest. 2014 Nov 03;124(11):4895-8. doi: 10.1172/JCI76658
Polarization of prostate cancer-associated macrophages is induced by milk fat globule-EGF factor 8 (MFG-E8)-mediated efferocytosis
Soki FN, Koh AJ, Jones JD, Kim YW, Dai J, Keller ET, Pienta KJ, Atabai K, Roca H, McCauley LK.
J Biol Chem. 2014 Aug 29;289(35):24560-72. doi: 10.1074/jbc.M114.571620
Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids
Khalifeh-Soltani A, McKleroy W, Sakuma S, Cheung YY, Tharp K, Qiu Y, Turner SM, Chawla A, Stahl A, Atabai K.
Nat Med. 2014 Jan 19;20(2):175-83. doi: 10.1038/nm.3450
Functional genomic screen identifies novel mediators of collagen uptake.
Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K.
Mol Biol Cell. 2014 Mar 01;25(5):583-93. doi: 10.1091/mbc.E13-07-0382
Always cleave up your mess: targeting collagen degradation to treat tissue fibrosis
McKleroy W, Lee TH, Atabai K.
Am J Physiol Lung Cell Mol Physiol. 2013 Jun 01;304(11):L709-21. doi: 10.1152/ajplung.00418.2012
Mfge8 suppresses airway hyperresponsiveness in asthma by regulating smooth muscle contraction
Kudo M, Khalifeh Soltani SM, Sakuma SA, McKleroy W, Lee TH, Woodruff PG, Lee JW, Huang K, Chen C, Arjomandi M, Huang X, Atabai K.
Proc Natl Acad Sci USA. 2013 Jan 08;110(2):660-5. doi: 10.1073/pnas.1216673110
IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction
Kudo M, Melton AC, Chen C, Engler MB, Huang KE, Ren X, Wang Y, Bernstein X, Li JT, Atabai K, Huang X, Sheppard D.
Nat Med. 2012 Mar 04;18(4):547-54. doi: 10.1038/nm.2684
Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages
Atabai K, Jame S, Azhar N, Kuo A, Lam M, McKleroy W, Dehart G, Rahman S, Xia DD, Melton AC, Wolters P, Emson CL, Turner SM, Werb Z, Sheppard D.
J Clin Invest. 2009 Dec 01;119(12):3713-22. doi: 10.1172/JCI40053
Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis
Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC.
Proc Natl Acad Sci USA. 2007 Jul 17;104(29):12005-10. doi: 10.1073/pnas.0704756104
Roles of the innate immune system in mammary gland remodeling during involution
Atabai K, Sheppard D, Werb Z.
J Mammary Gland Biol Neoplasia. 2007 Feb 08;12(1):37-45. doi: 10.1007/s10911-007-9036-6
Mfge8 is critical for mammary gland remodeling during involution
Atabai K, Fernandez R, Huang X, Ueki I, Kline A, Li Y, Sadatmansoori S, Smith-Steinhart C, Zhu W, Pytela R, Werb Z, Sheppard D.
Mol Biol Cell. 2005 Dec 01;16(12):5528-37. doi: 10.1091/mbc.e05-02-0128
Aerosolized beta(2)-adrenergic agonists achieve therapeutic levels in the pulmonary edema fluid of ventilated patients with acute respiratory failure
Atabai K, Ware LB, Snider ME, Koch P, Daniel B, Nuckton TJ, Matthay MA.
Intensive Care Med. 2002 May 17;28(6):705-11. doi: 10.1007/s00134-002-1282-x
Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms
Atabai K, Ishigaki M, Geiser T, Ueki I, Matthay MA, Ware LB.
Am J Physiol Lung Cell Mol Physiol. 2002 Jul 01;283(1):L163-9. doi: 10.1152/ajplung.00396.2001
The pulmonary physician in critical care. 5: Acute lung injury and the acute respiratory distress syndrome: definitions and epidemiology
Atabai K, Matthay MA.
Thorax. 2002 May 01;57(5):452-8. doi: 10.1136/thorax.57.5.452
Human eosinophils induce mucin production in airway epithelial cells via epidermal growth factor receptor activation
Burgel PR, Lazarus SC, Tam DC, Ueki IF, Atabai K, Birch M, Nadel JA.
J Immunol. 2001 Nov 15;167(10):5948-54. doi: 10.4049/jimmunol.167.10.5948
Pulmonary edema fluid from patients with acute lung injury augments in vitro alveolar epithelial repair by an IL-1beta-dependent mechanism
Geiser T, Atabai K, Jarreau PH, Ware LB, Pugin J, Matthay MA.
Am J Respir Crit Care Med. 2001 May 01;163(6):1384-8. doi: 10.1164/ajrccm.163.6.2006131
Increased expression of CD23 (Fc(epsilon) receptor II) by peripheral blood monocytes of AIDS patients
Miller LS, Atabai K, Nowakowski M, Chan A, Bluth MH, Minkoff H, Durkin HG.
AIDS Res Hum Retroviruses. 2001 Mar 20;17(5):443-52. doi: 10.1089/088922201750102544
Interleukin-1beta augments in vitro alveolar epithelial repair
Geiser T, Jarreau PH, Atabai K, Matthay MA
Am J Physiol Lung Cell Mol Physiol. 2000 Dec 01;279(6):L1184-90. doi: 10.1152/ajplung.2000.279.6.L1184